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Lee, 23, originally entered the NFL as a rookie free agent with the Houston Texans on May 6, 2016 out of South Florida. The 6-foot-3, 260-pounder, spent his rookie season on the Houston practice squad and was released by the Texans prior to the start of the 2017 regular season. Lee joined the Buffalo Bills practice squad on September 5, and was added to the 53-man roster on September 29. He was active for the Bills Week 4 matchup against Atlanta but did not play. Lee was released on October 3 and re-joined the Buffalo practice squad on October 5.