This week's game will be the 81st encounter between the two AFC East rivals, dating back to the inception of the AFL in 1960. This will be the first meeting of the season between these two teams and the sixth division game the Patriots have played this season. The Bills currently have a two-game winning streak against the Patriots, their first multiple game streak since they had won five consecutive games from 1992-94. The results of the series are listed below:
| **DATE** | **RESULT** | **/-** |
| 1960 | Buffalo 13, at NE 0 | -13 |
| at Buffalo 38, NE 14 | -24 | |
| 1961 | NE 23, at Buffalo 21 | 2 |
| at NE 52, Buffalo 21 | 31 | |
| 1962 | at Buffalo 28, NE 28 | tie |
| at NE 21, Buffalo 10 | 11 | |
| 1963 | at Buffalo 28, NE 21 | -7 |
| at NE 17, Buffalo 7 | 10 | |
| 1964 | NE 36, at Buffalo 28 | 8 |
| Buffalo 24, at NE 14 | -10 | |
| 1965 | at Buffalo 24, NE 7 | -17 |
| Buffalo 23, at NE 7 | -16 | |
| 1966 | NE 20, at Buffalo 10 | 10 |
| at NE 14, Buffalo 3 | 11 | |
| 1967 | NE 23, at Buffalo 0 | 23 |
| Buffalo 44, at NE 16 | -28 | |
| 1968 | NE 16, at Buffalo 7 | 9 |
| at NE 23, Buffalo 6 | 17 | |
| 1969 | at Buffalo 23, NE 16 | -7 |
| at NE 35, Buffalo 21 | 14 | |
| 1970 | Buffalo 45, at NE 10 | -35 |
| NE 14, at Buffalo 10 | 4 | |
| 1971 | at NE 38, Buffalo 33 | 5 |
| at Buffalo 27, NE 20 | -7 | |
| 1972 | at Buffalo 38, NE 14 | -24 |
| Buffalo 27, at NE 24 | -3 | |
| 1973 | Buffalo 31, at NE 13 | -18 |
| at Buffalo 37, NE 13 | -24 | |
| 1974 | at Buffalo 30, NE 28 | -2 |
| Buffalo 29, at NE 28 | -1 | |
| 1975 | at Buffalo 45, NE 31 | -14 |
| Buffalo 34, at NE 14 | -20 | |
| 1976 | NE 26, at Buffalo 22 | 4 |
| at NE 20, Buffalo 10 | 10 | |
| 1977 | Buffalo 24, at NE 14 | -10 |
| NE 20, at Buffalo 7 | 13 | |
| 1978 | NE 14, at Buffalo 10 | 4 |
| at NE 26, Buffalo 24 | 2 | |
| 1979 | NE 26, at Buffalo 6 | 20 |
| Buffalo 16, at NE 13(OT) | -3 | |
| 1980 | at Buffalo 31, NE 13 | -18 |
| at NE 24, Buffalo 2 | 22 | |
| 1981 | at Buffalo, 20, NE 17 | -3 |
| Buffalo 19, at NE 10 | -9 | |
| 1982 | at NE 30, Buffalo 19 | 11 |
| 1983 | NE 31, at Buffalo 0 | 31 |
| at NE 21, Buffalo 7 | 14 | |
| 1984 | NE 21, at Buffalo 17 | 4 |
| at NE 38, Buffalo 10 | 28 | |
| 1985 | NE 17, at Buffalo 14 | 3 |
| at NE 14, Buffalo 3 | 11 | |
| 1986 | NE 23, at Buffalo 3 | 20 |
| at NE 22, Buffalo 19 | 3 | |
| 1987 | at NE 14, Buffalo 7 | 7 |
| NE 13, at Buffalo 7 | 6 | |
| 1988 | Buffalo 16, at NE 14 | -2 |
| at Buffalo 23, NE 20 | -3 | |
| 1989 | at Buffalo 31, NE 10 | -21 |
| at NE 33, Buffalo 24 | 9 | |
| 1990 | Buffalo 27, at NE 10 | -17 |
| at Buffalo 14, NE 0 | -14 | |
| 1991 | at Buffalo 22, NE 17 | -5 |
| at NE 16, Buffalo 13 | 3 | |
| 1992 | Buffalo 41, at NE 7 | -34 |
| at Buffalo 16, NE 7 | -9 | |
| 1993 | at Buffalo 38, NE 14 | -24 |
| Buffalo 13, at NE 10 (OT) | -3 | |
| 1994 | Buffalo 38, at NE 35 | -3 |
| NE 41, at Buffalo 17 | 24 | |
| 1995 | at NE 27, Buffalo 14 | 13 |
| NE 35, at Buffalo 25 | 10 | |
| 1996 | at Buffalo 17, NE 10 | -7 |
| at NE 28, Buffalo 25 | 3 | |
| 1997 | at NE 33, Buffalo 6 | 27 |
| NE 31, at Buffalo 10 | 21 | |
| 1998 | at Buffalo 13, NE 10 | -3 |
| at NE 25, Buffalo 21 | 4 | |
| 1999 | at Buffalo 17, NE 7 | -10 |
| Buffalo 13, at NE 10 (OT) | -3 | |
| 1963 | *NE 26, at Buffalo 8 | 18 |
The Patriots have won four of the last five game in the series at Foxboro Stadium … Three of the last four games in the Patriots-Bills series have been decided by four points or less … The Patriots have 41 victories over the Bills, their highest total against any team … This weekend's game will be the first time the Patriots have played a Bruce Smith-less Buffalo Bills team since Nov. 11, 1984 – a span of 30 games … Bledsoe has thrown 22 touchdowns compared to only nine interceptions in 14 career games against the Bills.
There have been numerous outstanding individual performances in the series between the Patriots and the Bills. Below is a list of the top individual efforts based on yards gained:
| **Rushing Yards** | |
| Patriots: | Jim Nance 34-185-1 td (9/24/67) |
| Bills: | O.J. Simpson 29-250-2 tds (9/16/73) |
| **Passing Yards** | |
| Patriots: | Drew Bledsoe 42-36-2-380-3 tds-2 ints (9/11/94) |
| Bills: | Jim Kelly 41-21-356-1 td-2 ints (11/19/89) |
| **Receiving Yards** | |
| Patriots: | Stanley Morgan 5-158-2 tds (11/4/79) |
| Bills: | Andre Reed 9-168-1 td (9/27/92) |
The New England Patriots lost 13-10 to the Buffalo Bills at Foxboro Stadium on Dec. 26, 1999. Bills' kicker Steve Christie converted a 23-yard field goal with 1:51 remaining in overtime to give the Bills the victory.
New England's kicker, Adam Vinatieri missed two opportunities to win the game when a 33-yard field goal was wide right at the end of regulation and a 44-yard attempt fell short in overtime. Vinatieri had made 14 consecutive kicks before missing three of four attempts versus the Bills.
The Patriots rushed 34 times for 158 yards (4.6 average) against the Bills, who were only allowing 83.4 yards (third in the NFL) entering the game. It was the second highest total against them last season. Patriots running back Terry Allen led the charge with 126 yards rushing on 27 carries (4.7 avg.) and one touchdown. It was the highest individual rushing total against the Bills last season.
At the beginning of the fourth quarter, Patriots Chad Eaton recovered a Bills fumble and returned it 30-yards to the Bills 14-yardline. On the very next play, Allen scored from 14 yards out and the Patriots captured the lead, 10-3. Unfortunately, Buffalo tied the score midway through the fourth quarter on a 1-yard touchdown run.
The Patriots won the overtime coin toss and drove down into field goal position. Unfortunately Vinatieri missed another field goal, a 44-yard attempt, that could have won the game. Buffalo would later drive 52 yards on 10 plays and Christie ended the game with his 23-yard field goal.
