FOXBOROUGH, Mass. -- Alfonzo Dennard watched himself on the video board as he raced 87 yards with an interception for a touchdown. He wanted to see if the star rookie who threw the pass might catch him.
The way the New England Patriots were playing - with their usual strong offense, big plays on defense and a touchdown on a punt return - there was no way Andrew Luck and the Indianapolis Colts could overtake them.
The Patriots, the NFL's highest-scoring team, equaled their single-game scoring record for points with a 59-24 win on Sunday.
"The coaches want us to play aggressive," Dennard said, whose touchdown made it 45-17. "So that's what I was doing out there."
The first matchup between three-time Super Bowl winner Tom Brady and star rookie Luck was no match. Brady threw three touchdown passes. Luck threw three interceptions.
"They're good enough," Luck said. "They don't need those gifts, but to their credit, they created those and we didn't."
They may need them more after tight end Rob Gronkowski left the field with what the Patriots said was an arm injury with about four minutes left in the game. Comcast SportsNet New England reported X-rays showed Gronkowski had a broken arm. Neither the team nor Comcast SportsNet specified which arm was hurt.
Gronkowski caught two touchdown passes Sunday, giving him seven touchdown receptions in his last four games and 10 for the season. He finished the game with seven catches for 137 yards, The Patriots' other valuable tight end Aaron Hernandez missed his third straight game and sixth overall after spraining his right ankle.
The Patriots' much-maligned pass defense finally made major contributions as newcomer Aqib Talib returned another interception for a touchdown, covering 59 yards. And Rob Ninkovich's fifth forced fumble of the season - knocking the ball out of Luck's hand - set up Gronkowski's second scoring grab on the next play.
"We knew we couldn't come here and turn the football over and have a chance to win," Colts interim coach Bruce Arians said. "We've got a lot of rookies out there so every week is a learning experience. It was a bad learning experience."
The Patriots (7-3) won their fourth straight game and extended their lead in the AFC East to three games over the other three teams. The Colts (6-4) had their four-game winning streak stopped by the NFL's best offense and one of its worst defenses.
Now New England must hurry to prepare for its Thanksgiving night meeting with the Jets (4-6). New York ended a three-game slide with a 27-13 win over the St. Louis Rams.
"I don't think we're anywhere (near) where we need to be at this point," Brady said.
For the Patriots, Sunday's win was their most complete in a season in which they've averaged 35.8 points per game and lost their three games by a combined margin of four points.
The 59 points equals the team mark set in a 59-0 win over the Tennessee Titans on Oct. 18, 2009.
The Patriots also scored on a 68-yard punt return by Julian Edelman three plays before Talib gave the Patriots the lead for good, 21-14.
"I don't think guys panicked" after that one-two punch, Luck said. "Playing hard is not enough, as evidenced tonight."
Brady completed 24 of 35 passes for 331 yards and no interceptions. Luck was 27-for-50 passing for two touchdowns and 334 yards and set an NFL record as the first rookie with five 300-yard games.
The Colts were competitive for one half. The Patriots led 24-17 heading into the third quarter.
Then the Patriots scored on passes of 2 yards to Edelman and 24 yards to Gronkowski and Dennard's interception return.
Luck followed with a 43-yard scoring pass to T.Y. Hilton, the second of the game to the fellow rookie, But the Patriots responded with touchdown runs of 3 yards by Stevan Ridley and 4 yards by Shane Vereen.
The game began with touchdowns on the first three series: a 1-yard run by Delone Carter of the Colts, a 4-yard pass from Brady to Gronkowski, and a 14-yard pass from Luck to Hilton.
Stephen Gostkowski then missed a 36-yard field goal attempt for the Patriots.
But their fortunes changed four plays later. Edelman brought a punt back for a touchdown for the third time in his career after the defense forced Luck into a three-and-out. And just three plays and 61 seconds after that, the Patriots scored on Talib's touchdown to take the lead.
The catch was an easy one -- Luck threw the ball high over Reggie Wayne's head -- but the run was exceptional as Talib cut from the right side of the field to the left, eluding numerous Colts.
The Patriots obtained Talib from Tampa Bay before last Sunday's 37-31 win over Buffalo. But he sat that one out to complete a four-game suspension for violating the NFL policy on performance-enhancing substances.
"A lot of plays motivated the defense," Talib said. "About that third or fourth (Colts) series, we kind of got into it. It was kind of quiet out there early (then) we started talking."
Former Patriots kicker Adam Vinatieri, booed often in a stadium where he once was adored, cut the lead to 21-17 on a 47-yard field goal 5:46 before intermission.
Notes: The Patriots are 18-0 in the second half of the season starting in 2010. ... Luck broke Peyton Manning's NFL rookie record with his fifth game of at least 300 yards passing. ... Wes Welker stretched his streak to 104 games with at least one reception. ... Reggie Wayne tied Cris Carter's NFL mark with 58 consecutive games with at least three catches. ... Colts WR Donnie Avery left the game with a concussion. Arians had no update after the game.