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49ers RB Gore to miss at least two games with ankle injury

San Francisco 49ers running back Frank Gore is expected to miss three weeks because of a right ankle strain.

SANTA CLARA, Calif. -- San Francisco 49ers running back Frank Gore is expected to miss three weeks because of a right ankle strain.

The 49ers said Monday night that the strain was revealed during an MRI.

Gore injured the ankle on his only carry during Sunday's 27-24 loss to the Minnesota Vikings. He left the game after a four-yard gain and did not return.

Gore was taken to the locker room on a cart, but X-rays revealed no broken bones.

The team says the injury is not related to the ankle sprain Gore sustained during his 207-yard rushing performance against the Seattle Seahawks on Sept. 20.

Gore will miss Sunday's game against the St. Louis Rams and next week's game against the Atlanta Falcons. His place in the lineup will be taken by rookie Glen Coffee, who rushed for 54 yards on 25 carries at Minnesota.

The 49ers have their bye week Oct. 18, and Gore is expected to return for their Oct. 25 game at Houston.

San Francisco also said tackle Joe Staley is day-to-day with a bruised right thigh and safety Reggie Smith has a strained right groin that will be re-evaluated in two weeks.

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