Rob Gronkowski - The New England tight end has been held out of the end zone in consecutive weeks for just the second time this season. Gronkowski hasn't gone three weeks without a touchdown since early in 2011, so big No. 87 is due.
Tom Brady - No. 12 was under a decent amount of pressure last week in Green Bay. Now, he faces a Chargers front ranked 29'th in sacks per pass play and a defense that's allowed 30-plus points in three of its last five games.
Darrelle Revis - New England's shutdown corner clearly didn't feel good about allowing Jordy Nelson's 45-yard game-changing touchdown in Green Bay. Revis will have a chance to take out his coverage frustrations on second-year Chargers receiver Keenan Allen, far and away Philip Rivers top target.
Patrick Chung - The veteran safety has been a very impressive story in his second tour of duty in New England. But Chung has had his ups and downs in coverage and this week he'll likely see a good deal of potential future Hall of Famer Antonio Gates, who's aging but still productive.
LeGarrette Blount - In two games of his return to New England, Blount is averaging an impressive 6.2 yards per carry. The Chargers allow 4.3 yards a carry and have given up eight rushing touchdowns. #BlountForceTrauma
Philip Rivers - San Diego's quarterback is having a very impressive season, with a passer rating of 102.8 that's slightly higher than Tom Brady's. He's completing nearly 70 percent of his throws and leads one of the best third-down offenses (No. 3) in the game.
Ryan Matthews - The Chargers have not run the ball well in 2014, in part because Mathews missed seven games to injury. But the Patriots are still a bit suspect against the run at times and Mathews has found the end zone in each of the last two weeks.
Eddie Royal - Keenan Allen and Antonio Gates are the stars of the passing attack. But the veteran Royal has had a combined 15 catches in the last two weeks as he heads into a potential matchup with a New England corner who's either struggling (Logan Ryan) or banged up (Kyle Arrington).
Eric Weddle - San Diego's veteran Pro Bowl safety would be a key guy to keep an eye on even if he didn't have one of the NFL's best beards. (@weddlesbeard on Twitter!) Weddle is the Chargers play caller and key cog in the back end. He also might cross paths with Rob Gronkowski at times throughout the night.